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目的:探讨基质金属蛋白酶MMP-2、9及其抑制因子TIMP-1、2在子宫内膜异位症患者血清及腹腔液中的表达及意义。方法:收集37例EMs患者和25例对照组的血清及腹腔液标本,用ELISA法检测MMP-2、9及TIMP-1、2的水平。结果:EMs组血清和腹腔液中MMP-2、9的含量高于对照组(p<0.05);而TIMP-1、2的含量低于对照组(p<0.05)。EMs组Ⅲ~Ⅳ期血清和腹腔液中MMP-2、9的含量高于Ⅰ~Ⅱ期(p<0.05);而TIMP-1、2的含量低于Ⅰ~Ⅱ期(p<0.05)。结论:MMP-2、9及TIMP-1、2在EMs的发病中起着重要作用,检测血清及腹腔液中MMP-2、9及TIMP-1、2的水平对于EMs患者的诊断、疗效观察和预后判断有重要价值。
Objective: To investigate the expression of MMP-2, MMP-2, MMP-2, TIMP-1 and MMP-2 in serum and peritoneal fluid of patients with endometriosis. Methods: Serum and peritoneal fluid were collected from 37 patients with EMs and 25 controls. The levels of MMP-2, 9 and TIMP-1,2 were detected by ELISA. Results: The levels of MMP-2 and MMP-9 in serum and peritoneal fluid in EMs group were higher than those in control group (p <0.05), while the levels of TIMP-1,2 in serum and peritoneal fluid in EMs group were lower than those in control group (p <0.05). The levels of MMP-2 and MMP-9 in serum and peritoneal fluid from stage III to IV in EMs group were higher than those in stage I to II (p <0.05), while the levels of TIMP-1,2 in serum and peritoneal fluid were lower than those in stage I to II (p <0.05). Conclusion: MMP-2, 9 and TIMP-1,2 play an important role in the pathogenesis of EMs. The detection of MMP-2, 9 and TIMP-1,2 levels in serum and peritoneal fluid is of great value in the diagnosis and treatment of EMs And prognosis have important value judgments.