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目的 用气相色谱法测定氟乙酰胺(FAM)中毒儿童的药代动力学。方法 用血液灌流(HP)治疗3例FAM中毒的重症患儿;气相色谱法(GC法)检测FAM血药浓度。结果 在HP治疗后,3例FAM中毒的重度患儿12 h的FAM血药浓度若>90 mg.L-1时,可再用HP治疗。3例患儿HP治疗时的t1/2为(2.43±1.29) h,治疗后0～6 h和6～12 h的t1/2分别为(6.39±4.24) h和(14.90±13.71) h;2例患儿治疗中,当体内FAM的浓度<90 mg.L-1时,t1/2分别为0.70 h和2.00 h。结论 HP治疗FAM中毒患儿安全、有效,机体对FAM的消除呈浓度依赖性。
Objective To determine the pharmacokinetics of fluoroacetamide (FAM) poisoning in children by gas chromatography. Methods Hemotopoietic fluid (HP) was used to treat 3 severe FAM poisoning children. The plasma concentration of FAM was detected by gas chromatography (GC). Results After HP treatment, 3 severe FAM poisoning children with FAM plasma concentration of 12 h> 90 mg.L-1, HP can be re-treated. T1 / 2 was (2.43 ± 1.29) h in 3 cases of HP, and (6.39 ± 4.24) h and (14.90 ± 13.71) h in 0 ~ 6 h and 6 ~ In 2 children, t1 / 2 was 0.70 h and 2.00 h, respectively, when the concentration of FAM in the body was <90 mg.L-1. Conclusion HP treatment of children with FAM poisoning is safe and effective, and the elimination of FAM by the body is concentration-dependent.