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目的:采用光纤药物溶出度实时测定仪监测布洛芬缓释胶囊释放度。方法:用FODT仪和2005年版中国药典规定的溶出度及HPLC仪,分别检测4批布洛芬缓释胶囊的释放度,比较它们不同时段的平均累积释放百分率和总平均累积释放百分率。结果:两种方法相比,总平均累积释放百分率无明显差异(P>0.05)。结论:FODT仪监测布洛芬缓释胶囊释放度简便易行。
OBJECTIVE: To monitor the release of ibuprofen sustained-release capsules by optical fiber drug dissolution real-time analyzer. Methods: The release of four batches of ibuprofen sustained-release capsules was measured by FODT instrument and the dissolution rate and HPLC instrument as stipulated in the 2005 edition of Chinese Pharmacopoeia. The cumulative cumulative release percentages and the average cumulative cumulative release percentages of four batches of ibuprofen were compared. Results: There was no significant difference in the mean cumulative cumulative release percentage between the two methods (P> 0.05). Conclusion: It is simple and easy to monitor the release of ibuprofen sustained release capsules by FODT instrument.