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目的：探讨单纯修补术加术后药物治疗消化性溃疡穿孔的疗效。方法回顾性分析我院2005年1月~2014年7月收治的46例胃十二指肠溃疡穿孔患者的临床资料。结果本组无死亡病例，46例均治愈出院，效果良好。39例穿孔单纯修补术，35例随访时间1～3年，溃疡病已治愈，经胃镜确诊溃疡复发4例，均经再次抑酸、抗幽门螺旋杆菌治疗后症状缓解。结论行单纯修补术治疗十二指肠溃疡急性穿孔，术后行正规抗溃疡及根除幽门螺旋杆菌治疗能有效降低溃疡复发率，效果满意，是基层医院切实有效的治疗方法。“,”Objective To explore the effect of simple repair and postoperative medication on perforation of peptic ulcer. Methods Retrospective analysis of our hospital from January 2005 to July 2014 46 patients with gastroduodenal ulcer perforation in patients with clinical data. Results There were no deaths in this group, 46 cases were cured and discharged, the effect is good. 39 cases of perforation repair alone, 35 cases of follow-up time of 1 to 3 years, ulcer disease has been cured, confirmed by gastric ulcer recurrence in 4 cases, were again acid suppression, anti-Helicobacter pylori treatment symptoms. Conclusion The simple repair of acute perforated duodenal ulcer, postoperative anti-ulcer and anti-ulcer eradication treatment can reduce ulcer recurrence rate, satisfactory results, is an effective and effective treatment of primary hospital.