随着细胞和分子生物学的发展人们已着手骨肉瘤和Ewing’s肉瘤的细胞生物学研究。目前认为,骨肉瘤与具有生长抑制的视网膜母细胞瘤基因和蛋白质生长因子产生异常有关,肿瘤细胞DNA含量和细胞遗传学研究有助于骨肉瘤诊断和预后的确定。Ewing’s肉瘤和恶性神经细胞瘤表现为特征性第11和22号染色体易位,因而认为Ewing’s肉瘤可能起源于神经外胚层和间叶组织。 With the development of cell and molecular biology, people have begun to study the cell biology of osteosarcoma and Ewing’s sarcoma. At present, it is considered that osteosarcoma is associated with abnormal production of retinoblastoma gene and protein growth factor with growth inhibition. DNA content and cytogenetics of tumor cells contribute to the diagnosis and prognosis of osteosarcoma. Ewing’s sarcoma and malignant neuroblastomas exhibit characteristic chromosome 11 and 22 translocations. Therefore, Ewing’s sarcoma may be thought to have originated in neuroectodermal and mesenchymal tissues.