酒精性肝病(ALD)是长期过量饮酒导致的多种肝脏疾病~([1]),其主要包括轻症ALD、酒精性脂肪肝、酒精性肝炎、酒精性肝纤维化和酒精性肝硬化等5种类型~([2])。在我国,随着饮食结构和生活方式的改变,ALD患病率呈逐年上升趋势。L-精氨酸是一种人体半必需氨基酸,其游离态质量不稳定,因此通常将其制成复盐的形式保存。L-精氨酸-α酮戊二酸盐,简称精酮合剂(AAKG),是由L-精氨酸与α-酮戊二酸络合形成 Alcoholic liver disease (ALD) is a variety of liver diseases caused by long-term excessive alcohol consumption ([1]), which mainly includes mild ALD, alcoholic fatty liver, alcoholic hepatitis, alcoholic liver fibrosis and alcoholic cirrhosis 5 types ~ ([2]). In our country, with the change of diet structure and lifestyle, the prevalence of ALD is increasing year by year. L-arginine is a human semi-essential amino acids, its free-state quality is not stable, it is usually made in the form of double salt preservation. L-arginine-α-ketoglutarate, abbreviated as spermine ketone (AAKG), is formed by the complexation of L-arginine and α-ketoglutarate