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目的：研究热休克蛋白70（HSP70）与经皮冠状动脉腔内成形术后再狭窄形成中细胞增生的关系。方法：复制家兔颈总动脉球囊损伤模型，用免疫组化方法检测术后3、9、14、28d损伤动脉壁中HSP70和增殖细胞核抗原（PC－NA）表达水平；用计算机图像分析系统定量，并对两者进行相关分析。结果：损伤动脉壁HSP70及PCNA检测呈阳性，正常动脉呈阴性。9d时两者表达指数均较各自3d时显著升高，14d均达峰值，28d显著降至3d时水平。时相相关分析两者显著正相关。结论：细胞增生活性升高伴随HSP70的产生增多；动脉损伤时机体可能通过HSP70合成增多而促进细胞再生，一定程度上促成再狭窄。
Objective: To investigate the relationship between heat shock protein 70 (HSP70) and cell proliferation in restenosis after percutaneous transluminal coronary angioplasty. Methods: Rabbit models of common carotid artery balloon injury were duplicated and the expression of HSP70 and PCNA were detected by immunohistochemistry on the injured artery wall at 3, 9, 14 and 28 days after operation. A computer image analysis system Quantitative, and the two related analysis. Results: HSP70 and PCNA were detected in the damaged artery wall and normal artery was negative. On the 9th day, the expression index of the two groups were significantly higher than that of the other three days, reached the peak on the 14th day, and dropped to the level on the 28th day. Correlation analysis showed that there was a significant positive correlation between them. CONCLUSION: Increased cell proliferation accompanied by an increased production of HSP70. In arterial injury, the body may promote cell regeneration by increasing the synthesis of HSP70, and to some extent, causing restenosis.