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目的为了解肺泡巨噬细胞（ＡＭ）释放的肿瘤坏死因子α（ＴＮＦα）、血栓素Ｂ２（ＴｘＢ２）、６酮－前列腺素Ｆ１α（６－ｋｅｔｏ－ＰＧＦ１α）在慢性支气炎发病中的作用。方法应用支气管肺泡灌洗（ＢＡＬ）技术采集１２例慢性支气管炎缓解期患者和１２例正常人的肺泡巨噬细胞，进行体外培养并测定上述３种细胞因子含量。结果慢支组ＡＭ合成分泌的３种细胞因子含量均较正常人组高（Ｐ＜０．０５）；随着培养液中ＬＰＳ浓度的增加，两组ＡＭ合成分泌的３种细胞因子含量均逐渐增加，两组间存在显著差异性（Ｐ＜０．０５）。结论慢支缓解期患者ＡＭ更易活化释放这些炎性介质，对慢支发生发展有重要影响。
Objective To investigate the role of tumor necrosis factor α (TNFα), thromboxane B2 (TxB2) and 6-keto-PGF1α released by alveolar macrophages (AM) in the pathogenesis of chronic bronchitis. Methods Alveolar macrophages from 12 patients with chronic bronchitis and 12 normal controls were collected by bronchoalveolar lavage (BAL) technique and cultured in vitro. The above three cytokines were determined. Results The levels of three cytokines secreted by AM in chronic bronchitis group were higher than those in normal control group (P <0.05). With the increase of LPS concentration in culture medium, the contents of three cytokines secreted by AM were gradually increased Increase, there was significant difference between the two groups (P <0.05). Conclusion AM is more likely to activate and release these inflammatory mediators in patients with chronic bronchial remission, which has an important influence on the development of chronic bronchitis.