保守疗法治疗儿童坏死性筋膜炎

来源 :世界核心医学期刊文摘(儿科学分册) | 被引量 : 0次 | 上传用户:woshihanxue
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
Background: Necrotizing fascitis (NF) is a severe infection of the subcutaneous tissue and fascia affecting children and adults.Conventional management includes resuscitation, aggressive debridement of necrotic tissue, and sometimes, additional measures such as hyperbaric oxygen and immunoglobulin therapy.This paper reports conservative management of 18 patients with NF with minimal morbidity and mortality. Material and Methods:Patients with NF admitted to our department between January 2000 and February 2004 were included in the study (N= 18). In all cases, the presentation was rapidly progressing cellulitis progressing to cutaneous gangrene between 6 and 18 hours. The patients were managed by aggressive fluid resuscitation,analgesia, broad-spectrum antibiotics, and dressing with liberal quantities of povidone iodine ointment. After separation of the gangrenous skin margins from the surrounding healthy tissue between 24 and 72 hours, dead skin and fascia were removed with forceps on the ward, the wound washed with liberal quantities of water, and the ointment dressing reapplied.This procedure was repeated until all the dead tissue had been removed. Once the wound was granulating, dressings were changed at increasing intervals until healing took place by secondary intention. Results: The patients were aged between 5 days and 11 years. In all, NF began as a small boil progressing to a rapidly spreading cellulitis. None of the patients was operated during the acute stage of the infection. Blackening of the skin and separation of the edges occurred within 8-72 hours,the dead tissue was allowed to separate from the granulating base and could be removed at the bedside with minimal blood loss. Blood transfusion was required only in 2 patients where hemoglobin was < 9 mg/dL. Of the 18 patients, 6 grew group A streptococci and staphylococci in a polymicrobial wound culture, whereas the other 12 had polymicrobial flora without streptococci. The clinical course and outcomes were similar in both types of wounds. There was 1 death in the study group, and1 patient required skin grafting. All other survivors had healing by secondary intention without disability. The period for complete epithelization varied between 3 and 8 weeks. Patients were discharged home when 70%of the wound had healed.There was extensive scarring in 3 children with NF involving the back. The other children had minimal or no scarring. None of the patients had any restriction in the movement of limbs or joints. These findings were compared with 16 retrospective patients of NF treated before January 2000 by the conventional approach of aggressive early debridement, the results of the conservative approach were superior with shorter hospital stay, lower number of blood transfusions, earlier appearance of granulation tissue, and shorter duration of complete healing.Conclusions: We conclude that the conservative management of NF offers advantages in morbidity without compromising the outcome. In our hospital setup, conservative treatment was less expensive and easily carried out. We would therefore advocate conservative management for the treatment of this condition. Background: Necrotizing fascitis (NF) is a severe infection of the subcutaneous tissue and fascia affecting children and adults. Conventional management includes resuscitation, aggressive debridement of necrotic tissue, and sometimes, additional measures such as hyperbaric oxygen and immunoglobulin therapy. This paper reports conservative management of 18 patients with NF with minimal morbidity and mortality. Material and Methods: Patients with NF admitted to our department between January 2000 and February 2004 were included in the study (N = 18). In all cases, the presentation was rapidly progressing cellulitis progressing to cutaneous gangrene between 6 and 18 hours. The patients were managed by aggressive fluid resuscitation, analgesia, broad-spectrum antibiotics, and dressing with liberal quantities of povidone iodine ointment. After separation of the gangrenous skin margins from the surrounding healthy tissue between 24 and 72 hours, dead skin and fascia were removed with forceps on t he ward, the wound washed with liberal quantities of water, and the ointment dressing reapplied.This procedure was repeated until all the dead tissue had been removed. Results: The patients were aged between 5 days and 11 years. In all, NF began as a small boil progressing to a rapid spreading cellulitis. None of the patients was operated during the acute stage of the infection. Blackening of the skin and separation of the limbs occurred within 8-72 hours, the dead tissue was allowed to separate from the granulating base and could be removed at the bedside with minimal blood loss. Blood transfusion was required only in 2 patients where hemoglobin was <9 mg / dL. Of the 18 patients, 6 grew group A streptococci and staphylococci in a polymicrobial wound culture, while the other 12 had polymicrobial flora without streptococci. The clinical course and outcomes wThere was 1 death in the study group, and 1 patient required skin grafting. All other survivors had healing by secondary intention without disability. The period for complete epithelization varied between 3 and 8 weeks. Patients were discharged home when 70% of the wound had healed.There was extensive scarring in 3 children with NF involving the back. The other children had minimal or no scarring. None of the patients had any restriction in the movement of limbs or joints. These findings were compared with 16 retrospective patients of NF treated before January 2000 by the conventional approach of aggressive early debridement, the results of the conservative approach were superior with shorter hospital stay, lower number of blood transfusions, earlier appearance of granulation tissue, and shorter duration of complete healing .Conclusions: We conclude that the conservative management of NF offers advantages in morbidity without compromising the outcome. In our hospital setup, conservative treatment was less expensive and easily carried out. We would therefore advocate conservative management for the treatment of this condition.
其他文献
国家发改委价格监测中心编制的主要反映国际市场初级产品现货价格水平的中价国际A指数12月比上月下降2.91%,反映期货价格水平变化的中价国际B指数比上月下降3.96%。全年现货
一、当前的经济形势对于中国当前经济形势及其走势的判断与分析,基于国际上判断经济形势通常使用的四个指标——经济增长、通货膨胀、失业和国际收支。首先,从经济增长指标
四川石油管理局HSE委员会2月下旬成立了七个专业委员会,目的是在HSE委员会的领导下,让“安全环保工作在各个方面处于绝对受控状态”。 The HSE Committee of Sichuan Petrol
Background and Objectives. - The objective of this study was to investigate the prevalence and sociodemographic characteristics of headaches among Turkish adole
投资体制改革的实质是要建立起政企分开、权责明确,以企业为投资主体、市场调节为基础的管理体制和运行机制这里所说的改革开放早期,是指中共十一届三中会全决定对我国经济管
The scientific and technological development of CNOOC Limited entered a new stage during the Tenth Five-Year Plan period.High-tech researches in the company hav
This paper studied the appearance transition of microdischarges,the phase composition and the morphology evolution of the oxide film formed by microarc oxidatio
The effect of sliding duration on the tribological behaviors of spot patterned coatings was investigated. Two patterns based on physical vapor deposition (PVD)
教师到企业实践锻炼,是高职院校建设“双师”素质教师队伍的有效途径之一。当前高职院校采取措施积极促进专业教师到企业实践锻炼取得一定成效,但也存在一些问题,需要高职院
拔下耳机,揉揉微微泛痛的耳朵。不知道听了多久,我看着低电量自动关机的MP3,然后突然想起来,广播里一个甜美的声音说过:“长时间使用耳机,会导致耳内细菌过快增长,引发各种炎症……