论文部分内容阅读
Alberti等证明,抗前S2抗体不但不引起肝脏损害及自身免疫反应,而且有助于乙型肝炎病毒(HBV)的清除。 Vento等对一些患者从急性感染早期(最初的肝脏损害证据出现前30～70天)开始随访,进行一系列对HBV抗原的细胞免疫及体液免疫应答分析。结果发现,在HBV感染早期(血清转氨酶升高前30天)已可检出对前S2序列的T细胞免疫力,但不伴有感染的肝细胞坏死和抗前S2抗体产生,抗前S2抗体出现于临床后期,血清HBV-DNA消失之后,即在HBV已开始清除时。在无症状HBV携
Alberti et al. Demonstrated that anti-pre-S2 antibody not only does not cause liver damage and autoimmune reactions, but also contributes to the clearance of hepatitis B virus (HBV). Vento et al conducted a series of cellular and humoral immune response analyzes of some patients starting from the early stages of acute infection (30 to 70 days prior to the initial evidence of liver damage). As a result, it was found that T-cell immunity to the pre-S2 sequence was detected at the early stage of HBV infection (30 days prior to the rise of serum aminotransferase), but not associated with infected hepatocyte necrosis and production of anti-pre-S2 antibodies. Pre-S2 antibodies Appears in the clinical stage, after the disappearance of serum HBV DNA, that is, when HBV has begun to clear. Asymptomatic HBV carriers