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Fascin-2基因属于Fascins家族,其蛋白质编码产物是一组结构独特、进化保守的肌动蛋白交联蛋白,位于细胞膜皱襞、微棘突起及应力纤维,控制肌动蛋白细丝平行、有序、紧密排列与聚集。近年来研究发现,Fascin-2基因与连接以肌动蛋白为基本成分的纤毛质膜有密切联系,从而在感光器圆盘以及毛细胞静纤毛的形成中起重要作用,Fascin-2突变可引起原发性视网膜色素变性及渐进性的听力减退。就Fascin-2基因的研究进展进行阐述。
The Fascin-2 gene belongs to the Fascins family. Its protein coding product is a group of uniquely structured and evolutionarily conserved actin cross-linked proteins located in the folds of the cell membrane, the spines and micro-spines and stress fibers, which control the actin filament parallel, orderly, Closely arranged and gathered. Recent studies have found that Fascin-2 gene is closely related to the actin-based ciliated plasma membrane, which plays an important role in the formation of photoreceptor disk and hair cells. Fascin-2 mutation can cause Primary retinitis pigmentosa and progressive hearing loss. The research progress of Fascin-2 gene is described.