论文部分内容阅读
目的了解镉作业女工尿镉及血清中性激素水平改变的影响因素并初步探讨其机制。方法 2010年11月,选取某镉电池工厂镉作业女工100名作为接触组,按工作场所空气中镉含量的水平分成高、低2个接触浓度组;并选取来自同一家工厂未接触镉作业的50名女工作为对照组,测定3组人群的尿镉、促卵泡刺激素(FSH)、促黄体生成素(LH)及雌二醇(E2)的水平并进行统计分析。结果 2个接触组尿镉含量和异常率均明显高于对照组,差异有统计学意义(P<0.05,P<0.01);高浓度接触组工人在月经周期中的月经期血清中FSH水平和E2水平均低于对照组,差异均有统计学意义(P<0.01);增殖期血清中LH水平低于对照组,差异有统计学意义(P<0.01);分泌期血清中LH和E2水平均低于对照组,差异均有统计学意义(P<0.01)。结论在该研究的条件下,工作场所中氧化镉浓度超标是导致尿镉水平升高的主要危险因素;镉暴露可能对下丘脑-垂体-卵巢轴的性激素分泌功能造成影响,从而对女性工人的生殖系统产生内分泌干扰作用。
Objective To understand the influencing factors of urinary cadmium and serum levels of sex hormone in cadmium-exposed female workers and to explore its mechanism. Methods In November 2010, 100 cadmium workers in a cadmium battery factory were selected as the contact group, which were divided into two groups according to the level of cadmium in the air of the workplace. Two contact concentration groups were selected; and cadmium from the same factory Fifty female workers served as the control group, and the urinary cadmium, follicle stimulating hormone (FSH), luteinizing hormone (LH) and estradiol (E2) levels in three groups were measured and statistically analyzed. Results The urinary cadmium levels and abnormal rates in the two exposure groups were significantly higher than those in the control group (P <0.05, P <0.01). The FSH levels in the menstrual period serum in high exposure group were higher than those in the control group E2 levels were lower than the control group, the difference was statistically significant (P <0.01); LH level in proliferative phase serum was lower than the control group, the difference was statistically significant (P <0.01); LH and E2 serum levels during secrete Were lower than the control group, the difference was statistically significant (P <0.01). Conclusions Excessive cadmium concentrations in the workplace are the major risk factors leading to elevated urinary cadmium levels under the conditions of this study. Exposure to cadmium may have an impact on the sex hormonal secretion of the hypothalamic-pituitary-ovarian axis, The reproductive system produces endocrine disrupting effect.