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目的:探索中西医结合治疗糖尿病下肢动脉病变球囊扩张成形术(PTA)后再狭窄的临床疗效。方法:选择2014年12月-2015年12月期间经检查确诊的2型糖尿病合并下肢动脉病变且行PTA治疗患者共42例为研究对象,采用随机、单盲法将其分作两组,其中对照组21例给予常规基础治疗,观察组21例同时加服补阳还五汤,观察患者术后再狭窄情况并进行组间比较。结果:观察组患者术后6个月、12个月时血管再狭窄率分别为4.76%和38.10%,与对照组比较均明显降低(P<0.05)。观察组患者治疗后ABI(0.90±0.06)、TBI(0.58±0.06)、MDA(4.43±0.51)cm/s、MTA(4.34±0.51)cm/s与治疗前和对照组比较均有明显增加(P<0.05)。观察组患者治疗后VAS评分(1.37±0.33)和跛行距离评分(1.02±0.33)与治疗前和对照组比较均有明显改善(P<0.05)。结论:糖尿病下肢动脉病变PTA患者采取中西医结合治疗能够改善患肢缺血症状和疼痛症状,降低再狭窄率,可进行临床推广和应用。
Objective: To explore the clinical efficacy of integrated traditional Chinese and western medicine in the treatment of restenosis after balloon angioplasty (PTA) of diabetic lower extremity arterial disease. Methods: A total of 42 patients with type 2 diabetes mellitus complicated with lower extremity arterial disease diagnosed by PTA during the period of December 2014-December 2015 were selected as the study subjects, and were divided into two groups by randomized, single-blind method. The control group 21 cases were given routine basic treatment. 21 cases of observation group were served with Buyang Huanwu Decoction at the same time. The restenosis after operation was observed and compared between groups. Results: The restenosis rate of the observation group was 4.76% and 38.10% respectively at 6 months and 12 months after operation, which were significantly lower than those in the control group (P <0.05). The ABI (0.90 ± 0.06), TBI (0.58 ± 0.06), MDA (4.43 ± 0.51) cm / s and MTA (4.34 ± 0.51) cm / s in the observation group were significantly higher than those before treatment and in the control group P <0.05). VAS score (1.37 ± 0.33) and claudication distance score (1.02 ± 0.33) in observation group were significantly improved compared with those before treatment and control group (P <0.05). Conclusion: The treatment of diabetic lower extremity arterial disease in patients with PTA with Integrative Medicine can improve limb ischemia symptoms and pain symptoms, reduce the rate of restenosis, the clinical promotion and application.