一、发生率、发生机制与病型据日本1999年进行的药物性肝损害全国调查统计资料,起因药物判定为1种的1667例中由化疗药物引起者有122例占7·2%,仅次于抗生素(22·0%)、解热镇痛剂(11·9%)和消化系统疾病用药(7·4%)。部分的抗肿瘤药可能诱发中毒性肝损害,但应用中发生的肝损害几 First, the incidence rate, mechanism and type of disease According to the national survey of drug-induced liver damage conducted by Japan in 1999, there were 122 cases (16.2%) of the 1667 cases with causative agents identified as chemotherapeutic agents and only 7.2% Antibiotics (22.0%), antipyretics and analgesics (11.9%) and digestive system diseases (7.4%). Some antineoplastic drugs may induce toxic liver damage, but liver damage occurred in a few applications