从1948年临床应用糖皮质激素(下简称激素)以来,在抢救各种类型的休克症,治疗免疫性疾病等方面都发挥了重要的作用,目前已成为临床常用的药物;而且在长期医疗实践中,在适应症的选择,减少不良反应,探讨合理使用方法或与其他药物合用等方面,均积累了不少经验。现简要综述如下: 一、适应症的选择: (1)激素作为补充疗法用于急慢性肾上腺皮质功能不全的阿狄森氏症。(2)短期大剂量或冲击疗法用于急性应激状态,如感染中毒性或过敏性休克、感染中毒性脑病、成人呼吸窘迫综合征及严重毒血症等。(3)中、长程疗法用于变态反应性疾病、结缔组织病及与自身免疫有关的血液、肾脏、皮肤、眼等疾病或器官移植的排斥反应。(4)在综合治疗中,配合治疗恶性淋巴瘤、多发性骨髓瘤、白血病、难治性吸收不良综合征、溃疡性结肠炎、多发性硬化症、原发性和获 Since 1948 clinical application of glucocorticoid (hereinafter referred to as hormone), in the rescue of various types of shock disease, immune disease and other aspects have played an important role, has become a commonly used drugs in the clinic; but also in long-term medical practice In the choice of indications, reduce adverse reactions, to explore the rational use of methods or combined with other drugs, have accumulated a lot of experience. A brief summary is as follows: First, the indications of choice: (1) hormone as a complementary therapy for acute and chronic adrenal insufficiency Addison’s disease. (2) short-term high-dose or shock therapy for acute stress states, such as toxic or anaphylactic shock infection, toxic encephalopathy, adult respiratory distress syndrome and severe sepsis. (3), long-range therapy is used for the rejection of allergic diseases, connective tissue diseases and autoimmune diseases such as blood, kidneys, skin, eyes, or organ transplantation. (4) in the comprehensive treatment, with the treatment of malignant lymphoma, multiple myeloma, leukemia, refractory malabsorption syndrome, ulcerative colitis, multiple sclerosis, primary and acquired