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基质金属蛋白酶9（MMP－9）是基质金属蛋白酶家族中的重要一员，是锌离子依赖的细胞外基质（ ECM）的降解酶。 ECM 的重塑通过影响细胞的结构和功能参与多种疾病的病理过程。MMP－9作为ECM的主要降解酶，通过调控基质胶原成分的合成和降解，直接影响血管平滑肌细胞形态和功能，并在高血压血管重构过程中发挥重要作用。同时，MMP－9也有望成为心脑血管疾病特别是高血压的潜在标志分子。“,”As one of the most important members of matrix metalloproteinases ( MMPs) , matrix metallo-proteinase 9 ( MMP-9 ) is a zinc-dependent endopeptidase to degrade the components of the extracellular matrix ( ECM) .ECM remodeling is involved in many physiological and pathological processes via altering the structures and functions of cells.MMP-9 regulates the synthesis and degradation of collagen components of ECM and changes vascular smooth muscle cells(VSMCs) morphologically and functionally,which induces the vascular remodeling in hypertension.In addition,MMP-9 is also expected to be the potential biomarker in hypertension.