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目的对比观察埃索美拉唑与奥美拉唑治疗胃溃疡的临床效果。方法选择150例胃溃疡患者的临床资料,根据治疗方案的不同将150例患者分为观察组(n=75)和对照组(n=75),观察组采用埃索美拉唑治疗方案,对照组采用奥美拉唑治疗方案,对比两组患者治疗总有效率,并行统计学对比。结果经过2个疗程的连续治疗后,观察组患者治疗有效率94.7%,对照组治疗有效率84.0%,二者相比,差异存在统计学意义(P<0.05)。两组患者均为发生严重药物不良反应。结论埃索美拉唑与奥美拉唑治疗胃溃疡都能取得较为满意的临床效果,但埃索美拉唑抑酸作用全面,治疗总有效率明显优于奥美拉唑,值得临床推广应用。
Objective To compare the clinical effects of esomeprazole and omeprazole in the treatment of gastric ulcer. Methods Clinical data of 150 patients with gastric ulcer were selected. 150 patients were divided into observation group (n = 75) and control group (n = 75) according to the different treatment regimen. The observation group was treated with esomeprazole and the control group Group using omeprazole treatment options, compared the total effective rate of two groups of patients, parallel statistical comparison. Results After 2 courses of continuous treatment, the treatment group showed an effective rate of 94.7% and the control group achieved an effective rate of 84.0%. There was significant difference between the two groups (P <0.05). Two groups of patients were serious adverse drug reactions. Conclusions Both esomeprazole and omeprazole can achieve satisfactory clinical effects in the treatment of gastric ulcer. However, the overall acid suppression effect of esomeprazole is better than that of omeprazole, which is worthy of clinical application .