ＣＤＫＮ２基因位于人染色体９Ｐ２１～２２区，研究表明，其在各种恶性肿瘤中存在高频率的缺失、突变、甲基化和重排等变异。前列腺增生症（ＢＰＨ）是常见的老年男性疾病，其病因尚未阐明。为了探讨ＣＤＫＮ２基因与ＢＰＨ生物学行为之间的关系，我们采用ＳＳＣＰ技术分析 The CDKN2 gene is located on the human chromosome 9P21 ~ 22 region, studies have shown that it has a variety of malignant tumors with high frequency of deletion, mutation, methylation and rearrangement and other mutations. Benign prostatic hyperplasia (BPH) is a common disease of elderly men whose etiology has not been elucidated. In order to investigate the relationship between the CD-KN2 gene and the biological behavior of BPH, we used SSCP technique