水通道蛋白是位于细胞膜或细胞内囊泡能够通透水的蛋白质分子 ,其中水通道蛋白 2 (AQP2 )主要分布于肾脏集合管主细胞的管腔侧膜及近管腔侧的胞浆囊泡内 ,是抗利尿激素敏感型水通道。抗利尿激素可调节肾脏集合管AQP2的表达及穿梭 ,在肾脏水平衡调节中起重要作用 Aquaporin is located in the cell membrane or intracellular vesicles are permeable to water protein molecules, including aquaporin 2 (AQP2) is mainly distributed in the main tube of renal collecting manifold lumen and near the lumen side of the cytoplasmic vesicles Within, it is an anti-diuretic hormone-sensitive water channel. Antidiuretic hormone can regulate the expression of renal collecting tube AQP2 and shuttle, plays an important role in the regulation of renal water balance