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目的：了解血管内皮素（ＥＴ），超氧化物歧化酶（ＳＯＤ）与过氧化物脂质（ＬＰＯ），在椎一基底动脉缺血（ＶＢＩ）发病中的作用。方法：对３５例椎－基底动脉缺血患者和５９例健康体检者血浆血清进行ＥＴ、ＳＯＤ、ＬＰＯ检测，并作对照分析。结果：ＶＢＩ患者血浆ＥＴ和血清ＳＯＤ明显高于对照组，具有统计学差异；ＬＰＯ与对照组比，无统计学差异。结论：ＶＢＩ发病中，血管活性物质的参与是不可忽视的因素。ＶＢＩ患者存在脑卒中发生的潜在危险，对其治疗应按脑血管病Ⅱ级防治来进行。
Objective: To investigate the role of endothelin (ET), superoxide dismutase (SOD) and lipid peroxides (LPO) in the pathogenesis of vertebrobasilar artery ischemia (VBI). Methods: Plasma samples from 35 patients with vertebrobasilar ischemia and 59 healthy subjects were measured for serum ET, SOD and LPO levels and compared with each other. Results: Plasma ET and serum SOD in VBI patients were significantly higher than those in control group, with statistical significance. There was no significant difference between LPO and control group. Conclusion: The involvement of vasoactive substances in the pathogenesis of VBI can not be ignored. VBI patients have the potential risk of stroke, its treatment should be based on prevention and treatment of cerebrovascular disease to carry out.