问;是否需要进行血清筛检以便对血清阴性的成人和青少年接种疫苗,例如,检测孕妇的水痘和风疹抗体效价,以确定血清阴性者而对其进行保护? Plotkin医生答:水痘阳性史是一个很好的提示,即以前确实患过水痘;而表明以前未患过水痘的阴性史则不是非常特异的,仅1/4水痘病史阴性者无抗体。如不作血清学试验。将会对许多血清阳性者接种疫苗,使其抗体水平增高。我们既可先筛检,然后对血清阴性者接种,也可不作特异性抗体试验,对所有水痘病史阴性者接种。我们筛检住院病人时发现,3～5%对水痘无抵抗力,这是一组非常危险的人群。如将该比例推论到育龄妇女,她们将会从她们 Q. Is serum screening required for vaccination of seronegative adults and adolescents, eg testing for chickenpox and rubella antibody titer in pregnant women to identify seronegative patients for protection? Dr. Plotkin A. The history of varicella is A good tip is that you did have chickenpox before, but the negative history that shows no history of chickenpox is not very specific, with only a quarter of chickenpox negative. If no serological test. Many seropositive people will be vaccinated to raise their antibody levels. We can first screening, and then seronegative vaccination, but also for specific antibody test, vaccinated against all chicken pox negative. When we screen inpatients, we find that 3 to 5% are non-resistant to chickenpox, a very dangerous group of people. If you deduce this proportion to women of childbearing age, they will be from them