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目的:观察百令胶囊联合糖皮质激素治疗肺肾气虚型老年慢性阻塞性肺气肿的疗效以及对生活质量的影响。方法:92例老年慢性阻塞性肺气肿患者,随机分为对照组和治疗组,各46例。对照组给予地塞米松片治疗;治疗组在对照组治疗基础上口服百令胶囊治疗。2组疗程均为2周。检测第1秒最大呼气量(FEV1)、用力肺活量(FVC),计算出第1秒用力呼气容积占用力肺活量(FEV1/FVC)的百分比;治疗前后动脉血气指标,二氧化碳分压(PaCO_2)和氧分压(PaO_2),参照中文版健康调查简表(SF-36)评分。结果:2组治疗后FVC、FEV1及FEV1/FVC水平均明显升高,与本组治疗前比较,差异有统计学意义(P<0.01);治疗后,治疗组FVC、FEV1及FEV1/FVC均明显高于对照组,与对照组比较,差异有统计学意义(P<0.01)。2组治疗后PaO_2明显升高,PaCO_2明显下降,与本组治疗前比较,差异有统计学意义(P<0.01);治疗后,治疗组PaO_2明显高于对照组,PaCO_2明显低于对照组,与对照组比较,差异均有统计学意义(P<0.01)。结论:百令胶囊联合糖皮质激素干预可改善肺肾气虚型老年慢性阻塞性肺气肿患者的肺功能、血气水平及生活质量,值得临床应用。
Objective: To observe the effect of Bailing capsule combined with glucocorticoid on the treatment of senile chronic obstructive pulmonary emphysema of lung-kidney-qi-deficiency type and its effect on quality of life. Methods: 92 elderly patients with chronic obstructive pulmonary emphysema were randomly divided into control group and treatment group, with 46 cases in each group. The control group was treated with dexamethasone tablets. The treatment group was treated with oral Bailing capsule on the basis of the control group. The two groups were treated for 2 weeks. The FEV1 and FVC were used to calculate the FEV1 / FVC of the first second. Before and after treatment, the arterial blood gas index, the partial pressure of carbon dioxide (PaCO_2) And partial pressure of oxygen (PaO_2), with reference to the Chinese version of Health Survey Profile (SF-36) score. Results: After treatment, the levels of FVC, FEV1 and FEV1 / FVC were significantly increased in both groups (P <0.01). After treatment, the levels of FVC, FEV1 and FEV1 / FVC Which was significantly higher than that of the control group, and the difference was statistically significant (P <0.01) compared with the control group. After treatment PaO2 was significantly increased and PaCO2 significantly decreased compared with that before treatment in the two groups (P <0.01). After treatment, PaO2 in the treatment group was significantly higher than that in the control group, PaCO2 was significantly lower than the control group, Compared with the control group, the differences were statistically significant (P <0.01). Conclusion: The combination of Bailing capsule and glucocorticoid can improve lung function, blood gas and quality of life of patients with chronic obstructive pulmonary emphysema of lung-kidney-qi type, which is worthy of clinical application.