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[目的]探讨0.2%呋喃西林气囊上冲洗对呼吸机相关肺炎(VAP)的影响。[方法]96例气管切开行机械通气患者随机分为两组,每组各48例。生理盐水冲洗组为对照组(A组),给予4-5 ml生理盐水进行冲气囊冲洗;呋喃西林组(B组)应用同等数量的0.2%呋喃西林冲洗;两组其他治疗措施相同,气囊上冲洗8 h 1次。记录两组患者3、6、9、12、15 d气管切开气囊上和气囊下滞留物的细菌培养菌落数、呼吸机相关肺炎发生的例数,并进行统计学处理。[结果]B组细菌总量明显少于A组,差异具有统计学意义(P﹤0.01,);15 d后,发生VAP的例数A组为15例,B组为5例。两组比较,B组发生率明显低于A组(P﹤0.05)。[结论]0.2%呋喃西林气囊上冲洗对呼吸机相关肺炎的发生有预防作用。
[Objective] To investigate the effect of 0.2% nitrofurazone balloon flush on ventilator-associated pneumonia (VAP). [Methods] Ninety-six patients undergoing mechanical ventilation for tracheotomy were randomly divided into two groups, 48 patients in each group. The rats in the saline flush group were given the control group (group A) and 4-5 ml of saline were inflated. The nitrofurantine group (group B) was given the same amount of 0.2% nitrofurazone. The other two treatments were the same. h 1 times. The number of bacterial culture colonies and the number of ventilator-associated pneumonia in tracheotomy balloon and balloon-retented trachea were recorded at 3, 6, 9, 12 and 15 days in both groups and statistically analyzed. [Results] The total amount of bacteria in group B was obviously less than that in group A, the difference was statistically significant (P <0.01). After 15 days, the number of cases with VAP was 15 in group A and 5 in group B. The incidence of group B was significantly lower than that of group A (P <0.05). [Conclusion] Flushing on 0.2% nitrofurazone balloon could prevent ventilator-associated pneumonia.