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为探讨电磁辐射对大鼠妊娠结局、胎盘氧化损伤及Nrf2蛋白表达的影响,将20只妊娠清洁级SD大鼠随机分为对照组和辐射组,每组10只。辐射组每天以900 MHz(370μW/cm2)模拟手机频率电磁辐照4 h,连续20 d。观察孕鼠的妊娠结局(窝仔数、死胎数、胎盘指数及仔鼠的体重、身长、尾长),检测胎盘组织丙二醇(MDA)含量和超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)活力及胎盘蜕膜、绒毛组织核转录因子2(Nrf2)蛋白的表达水平。结果显示,与对照组相比,电磁辐射后妊娠大鼠的死胎率升高,胎盘指数降低,胎盘组织MDA的含量和SOD、GSH-Px活力均降低,胎盘蜕膜组织Nrf2蛋白的表达水平升高,差异均有统计学意义(P<0.05,P<0.01)。而两组的窝仔数和仔鼠体重、身长、尾长及绒毛组织中Nrf2蛋白的表达水平间比较,差异均无统计学意义(P>0.05)。提示妊娠期手机频率辐射可引起大鼠不良妊娠结局,可能与其加重胎盘组织氧化损伤及胎盘蜕膜组织Nrf2表达异常有关。
In order to investigate the effect of electromagnetic radiation on pregnancy outcome, placental oxidative damage and Nrf2 protein expression, 20 pregnant SD rats were randomly divided into control group and radiation group, with 10 rats in each group. The radiation group simulated electromagnetic radiation of mobile phone at 900 MHz (370 μW / cm2) for 4 h every day for 20 days. The pregnancy outcome (litter size, stillbirth, placenta index, body weight, body length and tail length of pregnant rats) was observed. The content of placental MDA and the activity of glutathione Peroxidase (GSH-Px) activity and placental decidual, chorionic tissue nuclear transcription factor 2 (Nrf2) protein expression levels. The results showed that compared with the control group, the stillbirth rate and the placental index of the pregnant rats after the electromagnetic radiation were decreased, the content of MDA and the activities of SOD and GSH-Px in the placenta decreased, the expression level of Nrf2 protein in the decidua High, the difference was statistically significant (P <0.05, P <0.01). There was no significant difference in the number of litter size and the expression of Nrf2 protein in the body weight, body length, tail length and villi between the two groups (P> 0.05). Suggesting that the frequency of mobile phone during pregnancy can cause adverse pregnancy outcomes in rats, which may be related to aggravating the oxidative damage of placenta tissue and abnormal expression of Nrf2 in placental decidua.