抗抑郁药的传统给药途径如口服给药往往存在生物利用度低、用药成本高、患者依从性较差等缺陷。抗抑郁药透皮给药系统(TDDS)研制可以极大提高药效,减少其不良反应,已成为国内外研究的热点。本文综述抑郁症的发病机制、抗抑郁药类型以及TDDS在抗抑郁药开发中的应用。 Traditional anti-depressant drug delivery routes such as oral administration often have low bioavailability, high cost of medication, patients with poor compliance and other defects. Development of antidepressant transdermal delivery system (TDDS) can greatly improve the efficacy and reduce its adverse reactions, which has become a hot research field at home and abroad. This article reviews the pathogenesis of depression, the types of antidepressants and the use of TDDS in the development of antidepressants.