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目的分析应用坎地沙坦联合钙离子阻滞剂对高血压并心肌肥厚的临床疗效。方法收集2014年3月~2015年7月于我院高血压科进行治疗的高血压并心肌肥厚的120例患者的临床资料,将其随机分为观察者和对照组,每组60例;观察组患者在常规治疗的基础上加用坎地沙坦联合钙离子阻滞剂进行治疗,对照组患者在常规治疗的基础上加用单纯钙离子阻滞剂进行降压治疗。于接受治疗后的1个月、2个月、3个月及4个月后分别监测患者的血压情况,并于治疗4个月后对患者进行心脏超声的检查,对比两组患者的左心室射血分数、左心室重量指数、左心室舒张末内径、室间隔厚度及左心室壁厚度,根据对比结果对两组治疗方法的临床疗效进行评估。结果在治疗1个月及2个月后两组患者的血压间无明显差异,无统计学意义(P>0.05),但在治疗3个月及4个月后监测血压发现,观察者患者血压明显低于对照组,差异具有统计学意义(P<0.05);治疗4个月后对患者进行心脏超声检查发现,观察组各项指标均优于对照组患者,差异具有统计学意义(P<0.05)。结论应用坎地沙坦联合钙离子阻滞剂对高血压并心肌肥厚患者有更好的临床效果,不仅可以长期有效地降低并稳定患者血压,而且还可以改善患者的心脏泵血功能,阻止心肌的进一步损伤,在临床上可大力推广使用。
Objective To analyze the clinical effect of candesartan plus calcium blockade on hypertension and myocardial hypertrophy. Methods The clinical data of 120 patients with hypertension and myocardial hypertrophy who were treated in our hospital from March 2014 to July 2015 were collected and randomly divided into observation group and control group with 60 cases in each group. The patients in the group were treated with candesartan combined with calcium blockers on the basis of routine treatment. The patients in the control group were treated with antihypertensive therapy with calcium ion blockers on the basis of routine treatment. The patients were monitored for blood pressure at 1 month, 2 months, 3 months and 4 months after treatment, and the patients underwent echocardiography 4 months after treatment. The left ventricle Ejection fraction, left ventricular mass index, left ventricular end-diastolic diameter, interventricular septum thickness and left ventricular wall thickness. According to the comparison results, the clinical efficacy of the two treatment methods was evaluated. Results There was no significant difference in blood pressure between the two groups after treatment for 1 month and 2 months (P> 0.05), but blood pressure was monitored at 3 and 4 months after treatment, and blood pressure (P <0.05). After 4 months of treatment, the patients underwent echocardiography, the indexes in the observation group were better than those in the control group (P <0.05), and the difference was statistically significant (P < 0.05). Conclusion The application of candesartan in combination with calcium blockade has a better clinical effect on patients with hypertension and myocardial hypertrophy. It not only can reduce and stabilize the blood pressure of patients in a long-term and effective manner, but also can improve the patient’s heart pumping function and prevent myocardial The further damage can be greatly promoted in clinical use.