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实验采用家兔40只,随机分成4组:①单纯服药组,用不同疗程和剂量;②感染治疗组;③感染对照组;④正常对照组,我们应用病理形态学、免疫荧光、特异性淋巴细胞转化试验和皮肤试验等项进行药物性肝损害发病机制的研究。实验结果表明本药所致肝损害主要是变态反应性(兼有Ⅲ及Ⅳ型)机制。我们看到实验动物肝内有重要的病理形态学变化,以单纯服药组较为明显,主要有肝自身免疫性肉芽肿(4/22),细胆管增生及其周围炎(21/22)等,分别经显著性检验,无显著差异(P>0.05),表明各项病变的发生及其程度与药量和疗程无平行关系。本实验组家兔肝脏病变除1只兔外均较轻。
40 rabbits were randomly divided into 4 groups: 1 simple medication group with different courses and doses; 2 infection treatment group; 3 infection control group; 4 normal control group, we applied pathological morphology, immunofluorescence, specific lymphoid Cell transformation tests and skin tests are used to study the pathogenesis of drug-induced liver damage. The experimental results show that the liver damage caused by this drug is mainly an allergic (both type III and type IV) mechanism. We observed that there were important pathological changes in the liver of the experimental animals, which were more obvious in the simple medication group, mainly including liver autoimmune granuloma (4/22), fine bile duct hyperplasia and peripheral inflammation (21/22), etc. After significant test, there was no significant difference (P>0.05), indicating that there was no parallel relationship between the incidence and degree of each lesion and the dose and duration of treatment. In this experimental group, rabbit liver lesions were lighter except for one rabbit.