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目的:观察中西医结合治疗原发性肾病综合征的疗效。方法:将76例原发性肾病综合征患者按入院顺序随机分为对照组37例和治疗组39例,对照组给予激素常规治疗,治疗组在对照组基础上加用黄芪白花蛇舌草汤口服,疗程4周。观察两组总体疗效、主要生化指标的改变以及副作用发生情况。结果:治疗组总有效率和完全缓解率分别为87.18%和46.15%,显著高于对照组78.38%和35.14%(P<0.05);治疗组治疗后24hUpro、血脂TC、TG显著降低,血清TP、ALB明显升高,LDL、HDL、BUN、Scr等指标亦有明显改善,与对照组比较,差异有统计学意义(P<0.05);治疗组在减轻水肿、降低感染率、减少复发等方面优于对照组,差异有统计学意义(P<0.05)。结论:中西医结合治疗原发性肾病综合征能显著降低尿蛋白,升高血清白蛋白,减轻激素的副作用,明显优于单纯西药治疗。
Objective: To observe the curative effect of integrated traditional Chinese and western medicine on primary nephrotic syndrome. Methods: A total of 76 patients with primary nephrotic syndrome were randomly divided into control group (n = 37) and treatment group (n = 39). The control group was given routine treatment with hormone. On the basis of the control group, Oral, treatment for 4 weeks. The two groups were observed the overall efficacy, the main biochemical changes and the occurrence of side effects. Results: The total effective rate and complete remission rate of the treatment group were 87.18% and 46.15%, respectively, which were significantly higher than those of the control group (78.38% vs 35.14%, P <0.05) , ALB was significantly increased, LDL, HDL, BUN, Scr and other indicators also significantly improved, compared with the control group, the difference was statistically significant (P <0.05); treatment group in reducing edema, reducing infection rate, reducing recurrence Better than the control group, the difference was statistically significant (P <0.05). Conclusion: Integrative Chinese and Western medicine treatment of primary nephrotic syndrome can significantly reduce urinary protein, increase serum albumin, reduce side effects of hormones, was significantly better than Western medicine alone.