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应用膜片钳全细胞记录技术研究了粉防己碱（ｔｅｔｒａｄｒｉｎｅ，Ｔｅｔ）对豚鼠心室肌细胞延迟整流钾电流（Ｉｋ）的影响。结果发现：（１）Ｔｅｔ１０－６ｍｏｌ／Ｌ对心室肌细胞Ｉｋ的外向部分有显著的激活作用。（２）Ｔｅｔ对Ｉｋ外向部分的激活作用呈剂量依赖性。阈浓度为３×１０－８ｍｏｌ／Ｌ，最大有效浓度为３×１０－５ｍｏｌ／Ｌ。（３）Ｔｅｔ使心室肌细胞Ｉｋ的外向部分呈时间依赖性增加。结果提示：Ｔｅｔ对Ｉｋ的外向部分有激活作用，这种激活作用可能是其降低心肌收缩力、抗高血压和抗心律失常的作用机制之一。
The effect of tetrandrine (Tet) on delayed rectifier potassium current (Ik) in guinea pig ventricular myocytes was investigated using patch-clamp whole-cell recording technique. The results showed that: (1) Tet10-6 mol/L had a significant activation effect on the outward portion of Ik in ventricular myocytes. (2) The effect of Tet on the outward activation of Ik was dose-dependent. The threshold concentration was 3×10-8 mol/L, and the maximum effective concentration was 3×10-5 mol/L. (3) Tet causes a time-dependent increase in the outward portion of Ik in ventricular myocytes. The results suggest that Tet has an activation effect on the outward portion of Ik, and this activation may be one of the mechanisms that reduce the myocardial contractility, antihypertensive and antiarrhythmic effects.