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目的探讨妊娠妇女血清25-OH维生素D早期预测妊娠期糖尿病(GDM)的价值。方法收集500例产检孕16～18周孕妇的血清。跟踪随访至孕中晚期,根据孕中晚期75g糖耐量结果确定GDM和糖耐量异常(IGT)。排除存在GDM高风险因素的孕妇后,分为GDM组和IGT组。再选取年龄、孕周相同的正常孕妇作为对照组,对三组血清25-OH维生素D浓度进行分析。结果 GDM的发生率为5.8%,IGT的发生率为5.6%。GDM组25-OH维生素D浓度明显高于IGT组和对照组(P<0.05,P<0.01);孕前体重指数(BMI)与血清25-OH维生素D浓度存在正相关。结论孕16～18周孕妇血清25-OH维生素D水平能够早期预测GDM的发生。
Objective To investigate the value of 25-OH vitamin D in pregnant women in the early prediction of gestational diabetes mellitus (GDM). Methods Serum samples of 500 pregnant women who were tested during pregnancy for 16-18 weeks were collected. Follow up to the second trimester of pregnancy, GDM and impaired glucose tolerance (IGT) were determined based on the results of 75g glucose tolerance test during the second trimester. Excluding the presence of high risk factors for GDM in pregnant women, divided into GDM group and IGT group. Select the same age and gestational age of normal pregnant women as a control group, the three groups of serum 25-OH vitamin D concentrations were analyzed. Results The incidence of GDM was 5.8% and the incidence of IGT was 5.6%. The concentration of 25-OH vitamin D in GDM group was significantly higher than that in IGT group and control group (P <0.05, P <0.01). There was a positive correlation between body mass index (BMI) before pregnancy and serum 25-OH concentration. Conclusion The level of serum 25-OH vitamin D in pregnant women from 16 to 18 weeks pregnant can predict the occurrence of GDM early.