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1997~2000年,我院救治急性大剂量异烟肼中毒3例,报告如下。1 临床资料例1:患者女,36岁,以全身强直性惊厥反复发作,神志不清50分钟就诊。患者面色青灰,恶心呕吐,二便失禁。发作间歇期两肺可闻及广泛痰鸣音。当即按癫痫大发作持续状态抢救,共静注地西泮60mg,肌注苯巴比妥钠200mg,10%水含氯醛30ml保留灌肠。终因强直性惊厥不能控制,呼吸反复中断,于1小时后因呼吸循环衰竭而死亡。死后呕吐物毒检提示异烟肼中毒,现场勘察,吞服量为15g。
1997 ~ 2000, our hospital for treatment of acute high-dose isoniazid in 3 cases, the report is as follows. 1 clinical data Example 1: Female patient, 36 years old, recurrent systemic tonic convulsions, delirious 50 minutes treatment. Patient looks pale gray, nausea and vomiting, second incontinence. Intermittent episodes of both lungs can be heard and extensive phlegm sounds. Epileptic immediate attack immediately sustained state, a total of intravenous diazepam 60mg, 200mg phenobarbital intramuscular injection, 10% water chloral hydrate 30ml retention enema. Due to uncontrollable tetanus convulsions, repeated respiratory failure, after 1 hour due to respiratory failure and death. Post-mortem vomit toxicity test indicates isoniazid poisoning, site investigation, swallowing volume of 15g.