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近年来HPLC 在药物分析与医学研究中的应用进展已见于诸综述,但有关强极性药物代谢物,尤其是药物酸性缀合代谢物的HPLC 分析尚少见报道。鉴于药物缀合物的种类、数量与排泄速率能反映宿主的生理状态、由于测定有效血药浓度时需排除缀合物干扰、评定药物代谢酶催化活性时需测定缀合物生成速率、研究药物代谢途径也需鉴定缀合物种类与生成量等原因,因而药物缀合物测定方法研究长期以来受到人们的重视。最早
In recent years, advances in the application of HPLC in drug analysis and medical research have been reviewed. However, the HPLC analysis of highly polar drug metabolites, especially the drug acidic conjugate metabolites, has not been reported yet. Given the type, amount, and excretion rate of drug conjugates, which reflect the physiological state of the host, the conjugate formation is determined by assessing the catalytic activity of the drug metabolizing enzyme as it is necessary to exclude conjugate interference when determining the effective plasma concentration, Metabolic pathway also need to identify the type of conjugate and the amount of formation and other reasons, and therefore the determination of drug conjugates for a long time by people’s attention. The earliest