整合蛋白作为参与细胞-细胞、细胞-细胞外基质间相互粘附的膜受体家族,与粘附分子上特异性的配体(含有RGD三肽结构)结合,形成配体-整合蛋白-细胞骨架跨膜信息系统,影响肿瘤的浸润、转移过程,它对于阐明肿瘤浸润、转移的分子机制及防治肿瘤转移意义重大。 Integrins act as a family of membrane receptors involved in cell-cell, cell-cell extracellular matrix adhesion, and bind to specific ligands on the adhesion molecule (containing an RGD tripeptide structure) to form ligand-integrin-cells. The transmembrane information system of the skeleton affects the infiltration and metastasis process of tumors. It is of great significance for elucidating the molecular mechanisms of tumor invasion and metastasis and preventing and treating tumor metastasis.