论文部分内容阅读
目的研究医院抗菌药物分级管理对医院感染病原菌分布及其耐药性的影响,以了解其变迁。方法通过临床病原学标本细菌分离鉴定和药敏试验,对某医院实施抗菌药物分级管理前后病原菌耐药性变化情况进行分析。结果在实施抗菌药物分级管理的连续3年期间,从住院患者送检标本中共分离鉴定出病原菌2 983株,其中革兰阴性菌占60.7%,革兰阳性菌占33.2%,真菌占6.1%。大肠埃希菌、肺炎克雷伯菌和聚团肠杆菌等3株革兰阴性菌对多数抗菌药物耐药率呈现下降趋势。革兰阳性菌耐药率变化不明显。结论抗菌药物分级管理后,医院感染病原菌种类分布无明显规律性变化,临床分离革兰阴性菌耐药率呈下降趋势,抗菌药物临床应用趋于合理。
Objective To study the impact of hospital antimicrobial agent classification on the distribution and drug resistance of pathogenic bacteria in hospital to understand the changes. Methods The bacterial etiology and drug susceptibility test of clinical etiological specimens were used to analyze the changes of drug resistance of pathogenic bacteria before and after the antimicrobial agents were administered in a hospital. Results A total of 2 983 pathogens were isolated from hospitalized patients during the three-year period of grading management of antibacterials, of which Gram-negative bacteria accounted for 60.7%, Gram-positive bacteria accounted for 33.2% and fungi accounted for 6.1%. Three strains of gram-negative bacteria such as Escherichia coli, Klebsiella pneumoniae and Enterobacter agglomerans showed a decreasing trend toward the majority of antibacterials. Gram-positive bacteria resistance rate change is not obvious. Conclusion The classification of nosocomial pathogenic bacteria showed no obvious regularity change after antibacterials were classified and managed. The drug resistance of gram-negative bacteria isolated from clinics showed a decreasing trend, and the clinical application of antibacterials tended to be rational.