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目的:研究叶黄素微囊在大鼠在体肠吸收特性。方法:采用单向灌流模型,紫外分光光度法测定在体肠灌流叶黄素微囊质量浓度的变化,研究不同肠段、不同质量浓度叶黄素微囊的吸收部位和吸收机制。结果:叶黄素微囊在大鼠各肠段的吸收速率常数(Ka)、有效渗透系数(Papp)是回肠>空肠>十二指肠>结肠,且各肠段的Ka,Papp值无显著性差异;灌流液中不同质量浓度叶黄素微囊的Ka,Papp值均无显著性差异。结论:叶黄素微囊在大鼠肠道无特定吸收窗,药物质量浓度对叶黄素微囊的Ka,Papp值无影响,其吸收机制为被动扩散。
Objective: To study the intestinal absorption characteristics of lutein microcapsules in rats. Methods: One-way perfusion model and UV spectrophotometry were used to determine the changes of lutein microcapsule mass concentration in intestinal perfused intestine and the absorption sites and absorption mechanism of lutein microcapsules in different intestinal segments and different concentrations. Results: The absorption rate constant (Ka), the effective permeability coefficient (Papp) of lutein microcapsules in the intestine of rats were ileum> jejunum> duodenum> colon, and there was no significant difference in the Ka and Papp values There was no significant difference in Ka and Papp values of lutein microcapsules with different concentration in perfusate. CONCLUSION: Lutein microcapsules have no specific absorption window in the intestine of rats. The drug concentration has no effect on the values of Ka and Papp of lutein microcapsules. The absorption mechanism is passive diffusion.