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目的 :探讨并建立植入用缓释氟尿嘧啶的人体内血浆浓度经时模型。方法 :分析体内过程 ,建立微分方程 ,求解与证明。结果 :经 19例试验者数据拟合 ,其人体内血药浓度经时模型为 :单室开放式模型 ,血药浓度方程C =A1 e-Ket+A2 e-Kat+A3e-Krt。结论 :此方程为植入剂药代动力学参数的计算提供理论参数。
Objective: To investigate and establish the model of human plasma concentration in vivo with sustained-release fluorouracil. Methods: Analyze in vivo processes, establish differential equations, solve and prove. Results: The data of 19 subjects were fitted. The model of human plasma concentration in time was single chamber open model and plasma concentration equation C = A1 e-Ket + A2 e-Kat + A3e-Krt. Conclusion: This equation provides theoretical parameters for calculating the pharmacokinetic parameters of implants.