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1目的 观察神经生长因子对新生儿缺氧缺血性脑病 (HIE)疗效。 2方法 将足月 HIE新生儿随机分为 A,B组 ,A组单用脑活素 ,B组用神经生长因子及脑活素治疗 ,并给予早期干预。生后 5 d内、发病后 18～ 2 5 d,90～ 180 d行头颅 CT平扫 ,发病后 18～ 2 5 d行新生儿行为神经测定 (NBNA) ,90～ 180 d行 Gesell发育量表检查。 3结果 B组在头颅 CT恢复程度、NBNA测定、智力测定等方面明显优于 A组 (χ2 =5 .31～ 9.11,P<0 .0 5 ;t=6 .95 ,P<0 .0 1)。 4结论 神经生长因子对促进 HIE病儿中枢神经系统功能恢复有明显作用
1 Objective To observe the effect of nerve growth factor on neonate hypoxic-ischemic encephalopathy (HIE). Methods 2 neonatal HIE full-term children were randomly divided into A, B group, A group of single-use cerebrolysin, B group with nerve growth factor and cerebrolysin treatment, and give early intervention. Within 5 days after birth, head CT scan was performed 18 to 25 days and 90 to 180 days after onset, behavioral neurological assessment (NBNA) of newborns from 18 to 25 days after onset, and Gesell’s developmental scale from 90 to 180 days an examination. 3 Results Group B in the recovery of head CT, NBNA determination, mental determination and other aspects were significantly better than the A group (χ2 = 5.31 ~ 9.11, P <0. 05; t = 6 .95, P < ). 4 Conclusion NGF promote the recovery of central nervous system function in children with HIE significant role