论文部分内容阅读
多以左旋多巴治疗震颤麻痹症(帕金森症),其作用机理为增高脑内神经递质多巴胺的水平。此外,嗅隐亭(bromoerivtine)等多巴胺神经受体激动剂也有治疗效果。多巴胺受单胺氧化酶的催化而代谢失活,应用单胺氧化酶抑制剂可延长多巴胺在脑内的存在时间。可是单胺氧化酶A抑制剂可产生高血压、心动过速等心血管副作用,因而不能应用单胺氧化酶A抑制剂或非特异性的单胺氧化酶抑制剂治疗震颤麻痹
Most levodopa treatment of Parkinsonism (Parkinson’s disease), its mechanism of action for increasing brain dopamine levels of neurotransmitters. In addition, dopamine nerve receptor agonists such as bromerivtine also have a therapeutic effect. Dopamine is catalyzed by monoamine oxidase and metabolically inactivated. The use of monoamine oxidase inhibitors prolongs the presence of dopamine in the brain. However, monoamine oxidase A inhibitors can produce cardiovascular and side effects such as hypertension and tachycardia and therefore can not be treated with monoamine oxidase A inhibitors or non-specific monoamine oxidase inhibitors for paralysis