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从27家医院空气中检出的330株金葡菌,在初代培养时,色素产生、菌落形状、溶血性质、菌体形态均发生了明显变异。经1~8代转种返祖后,恢复了与标准金葡菌相同的生物学特性,证明为非遗传型变异。药敏结果表明,本组菌对多种抗菌药物耐药率较高,广谱耐药株发生率达78.70%。并从中检出244株MRSA(73.94%)。MRSA的耐药率及耐药谱均显著地多于MSSA。提示此类非遗传型变异的金葡菌具有较强的致病力,是医院内感染的一个危险因素。
When 330 strains of Staphylococcus aureus were detected in the air of 27 hospitals, the pigment production, colony shape, hemolytic properties, and cell morphology all changed significantly during the initial culture. After the first to eighth generations were replanted, the same biological characteristics as those of standard S. aureus were recovered and proved to be non-genetic variants. Drug susceptibility results showed that the resistance rate of this group of bacteria to a variety of antibacterial drugs is high, and the incidence of broad-spectrum resistant strains reached 78.70%. 244 strains of MRSA (73.94%) were detected. The resistance rate and drug resistance spectrum of MRSA were significantly higher than that of MSSA. This suggests that non-genetic variants of S. aureus have strong virulence and are a risk factor for nosocomial infections.