本研究用不同剂量X线照射人离体血,观察由M_1细胞染色体畸变产额和常规方法建立的剂量效应关系有着相同的变化规律,均符合剂量效应关系。但是,前者明显高于后者,说明前者更灵敏,阳性率高。用该法建立的剂量效应关系,避免了畸变的丢失和衍生染色体畸变,能使剂量效应关系更接近实际,是制作刻度曲线较好的方法。 In this study, different doses of X-ray irradiation of human blood in vitro, observed by M_1 cell chromosome aberration yield and dose-effect relationship established by conventional methods have the same variation, are in line with the dose-response relationship. However, the former was significantly higher than the latter, indicating that the former is more sensitive and the positive rate is high. The dose-response relationship established by this method avoids the loss of distortion and derivation of chromosomal aberrations, and makes the dose-response relationship closer to reality. It is a good method for producing a calibration curve.