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采用ＧＨＲＨ＿（１－２９）每日６０μｇ／ｋｇ、３０μｇ／ｋｇ微泵腹部皮下持续输注，和ＧＨ每日０．１Ｕ／ｋｇ皮下注射治疗特发性下丘脑性ＧＨ缺乏性株儒症各２０例，治疗时间６个月，比较对生长速率的影响。结果表明：３组生长速率均有明显加速，分别为９．１±２．９ｃｍ／年、８．５±２．９ｃｍ／年和１３．８±３．０ｃｍ／年。前３个月治疗效果优于后３个月。ＧＨＲＨ治疗２组，治疗初３个月ＩＧＦ－１浓度持续升高，６个月时恢复到基值，而ＧＨ治疗组，治疗６个月时ＩＧＦ－１仍呈持续上升。ＧＨＲＨ血浓度随治疗时间延长呈持续上升。ＧＨＲＨ激发试验，ＧＨＲＨ治疗前、后６个月时，ＧＨ峰值后者明显大于治疗前基值。最后对上述现象进行了讨论。
Adopting GHRH (1-29) daily 60μg / kg, 30μg / kg micro pump subcutaneous continuous infusion, and GH daily 0.1U / kg subcutaneous injection treatment of idiopathic hypothalamic GH deficiency 20% For example, the treatment time of 6 months, compare the impact on growth rate. The results showed that the growth rates of three groups were significantly accelerated, 9.1 ± 2.9cm / year, 8.5 ± 2.9cm / year and 13.8 ± 3.0cm / year respectively. The first 3 months of treatment is better than after 3 months. GHRH treatment group 2, IGF-1 concentration continued to rise in the first 3 months of treatment, returned to the baseline value at 6 months, GH treatment group, IGF-1 still continued to rise at 6 months of treatment. GHRH blood concentration continued to rise with the treatment time. GHRH provocation test, GHRH treatment before and 6 months after the peak GH was significantly greater than the baseline before treatment. Finally, the above phenomenon was discussed.