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目的研究表皮生长因子受体（EGFR）在肾上腺皮质肿瘤中的表达意义。方法应用即用型链霉抗生物素蛋白一过氧化物酶链结法（S－P法）对25例肾上腺皮质肿瘤进行检测。结果EGFR在非瘤性病变中皮质球状带和网状带呈弱阳性表达，髓质不表达；在肾上腺皮质腺瘤中仅部分颗粒细胞呈弱阳性表达，透明细胞不表达；在肾上腺皮质腺癌中呈强阳性表达。结论EGFR的表达与肾上腺皮质肿瘤的生物学行为有关。
Objective To study the expression of epidermal growth factor receptor (EGFR) in adrenal cortical tumors. METHODS: Twenty-five cases of adrenal cortical tumors were examined using the streptavidin-peroxidase chain reaction (S-P method). RESULTS: EGFR was weakly positive in cortical girdle and reticular region in non-neoplastic lesions but not in medulla. Only some granulosa cells in adrenocortical adenomas were weakly positive and not in clear cells; in adrenocortical carcinoma In the strong positive expression. Conclusion The expression of EGFR is related to the biological behavior of adrenal cortical tumors.