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对69例用可乐定脱毒治疗的海洛因成瘾者进行药物不良反应(ADR)监测。结果表明:69例海洛因成瘾者可乐定ADR者69例,517例次,ADR发生率为100％;ADR表现最多的是口干(100％),乏力(100％),精神不振(100％),眩晕(95.6％),嗜睡(72.5％)等;这些症状出现时间较早,持续时间也较长;出现例次和权重总分在治疗2～4d最为严重,5d逐渐减轻;血压和心率在治疗2～5d多有下降,其中血压有15.9％患者,心率有8.7％患者低于正常值;幻觉和谵妄的出现率分别为11.6％和33.3％。针对可乐定不良反应发生率高,较为严重的研究结果,建议加强医疗护理工作,预防其不良反应所造成的危害。
Drug-adverse reactions (ADRs) were monitored in 69 heroin addicts treated with clonidine. The results showed that 69 cases of clonidine ADR were found in 69 cases of heroin addicts (517 cases), the incidence of ADR was 100%; the most common ADR was dry mouth (100%), weakness (100%), ), Dizziness (95.6%), drowsiness (72.5%), etc .; these symptoms appear earlier and longer duration; the total number of cases and weights in the treatment of 2 ~ 4d the most serious, 5d gradually reduced; blood pressure and heart rate In the treatment of 2 ~ 5d more than a decline, of which 15.9% of patients with blood pressure, heart rate 8.7% of patients below normal; the incidence of hallucinations and delirium were 11.6% and 33.3%. For the high incidence of adverse reactions of clonidine, the more serious findings, it is recommended to strengthen medical care, to prevent the harm caused by adverse reactions.