在近30年内,人们都在关注孕妇用药可能导致胎儿畸形的发生.然而研究证实.仅有几种药物与出生缺陷具有肯定的关联.早在60和70年代,Brockleband和Piper等曾对此发表过许多论述,但这些研究在设计、方法及目的方面都大相径庭.为此,作者利用巴尔的摩-华盛顿婴儿研究资料,对美国孕妇孕期使用处方药物和非处方药物进行了调查.以2752名分娩后无任何重要先天性畸形婴儿的母亲为研究对象.通过访谈了解其用药情况.从婴儿出生到访谈其母亲的平均时间为5.5个月,其中79%的访谈在分娩后7个月内进行,访谈内容包括母亲的健康状况、社会经济状况、婴儿出生前15个月母亲曾患急、慢性病、妇科疾病及用药史. In the past 30 years, people are concerned about the use of pregnant women may lead to fetal malformations, but studies have confirmed that only a few drugs and birth defects have a positive correlation as early as the 60s and 70s, Brockleband and Piper had published However, these studies differ widely in terms of design, methodology, and purpose, and the authors used the Baltimore-Washington Infant Research data to investigate the use of prescription and over-the-counter medications for pregnant women in the United States during pregnancy. An important mother of an infant with congenital anomalies was the subject of the study and interviewed about her medication was used. The average time from birth to interviewing her mother was 5.5 months, of which 79% were interviewed within 7 months after giving birth. The interview included Mother’s health, socioeconomic status, 15 months before the birth of the mother had a history of acute, chronic, gynecological diseases and medication.