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为观察氨基糖苷类新药８９－０７有无耳蜗毒性，采用豚鼠动脉插管直接输注给药，设生理盐水、乙基西梭霉素、庆大霉素作比较观察。通过一定音量的声频刺激，检测豚鼠耳廓反射结果显示８９－０７对听力的影响极小，与庆大霉素比较有非常显著性差异（Ｐ＜０．００１），与乙基西梭霉素组比较无明显差异（Ｐ＞０．０５），与生理盐水组比有差异（Ｐ＜０．０５）。实验提示８９－０７对耳蜗毒性极小。
To observe the aminoglycoside drug 89-07 with or without cochlear toxicity, the use of guinea pig arterial intubation direct infusion, set the saline, ethyl thiamethoxam, gentamicin for comparison. The audiometry of guinea pig through a certain volume of audible stimulation showed that the effect of 89-07 on hearing was extremely small and very significant difference compared with gentamicin (P <0.001) There was no significant difference between the two groups (P> 0.05), but there was a significant difference between the two groups (P <0.05). Experiments suggest that 89-07 is extremely toxic to the cochlea.