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目的探讨代谢综合征(MS)组分及不同组合与冠心病(CHD)患病风险的相关性,为CHD的预防控制提供参考依据。方法整群抽取2012年1—12月在首都医科大学附属北京友谊医院进行常规体检的18 254名≥18岁体检者进行问卷调查、体格检查和实验室检测,比较各MS组分、组分个数以及组分的不同组合形式与CHD患病的相关性。结果 18 254名≥18岁体检者中,M S患病率为29.83%,CHD患病率为1.05%;M S组分与CHD相关性分析结果显示,超重或肥胖、高血压、高甘油三酯血症、低高密度脂蛋白血症、高血糖或糖尿病5个M S组分均为CHD患病的危险因素(均P<0.01);MS组分个数与CHD相关性分析结果显示,当组分数为4个(OR=3.16,95%CI=1.94~5.14)和5个(OR=4.12,95%CI=1.59~10.72)时CHD患病风险较大;M S组分个数相同时不同组合情况与CHD相关性分析结果显示,组分个数为2时,体质指数(BMI)+高密度脂蛋白胆固醇(HDL-C)组CHD患病风险相对较低(OR=0.06,95%CI=0.02~0.24),血压(BP)+空腹血糖(FPG)组CHD患病风险相对较高(OR=4.60,95%CI=1.44~14.69);组分个数为3时,BP+FPG+HDL-C组CHD患病风险相对较高(OR=5.08,95%CI=1.15~22.40);组分个数为4时,BM I+BP+甘油三酯(TG)+FPG组(OR=4.38,95%CI=1.03~18.61)和BM I+BP+FPG+HDL-C组(OR=4.33,95%CI=1.20~15.66)CHD患病风险均相对较高。结论M S组分是CHD的危险因素,CHD患病风险随M S组分个数的增加而增加,组分个数相同时不同组合与CHD的相关性不同。
Objective To investigate the relationship between metabolic syndrome (MS) components and different combinations and the risk of coronary heart disease (CHD), and to provide a reference for the prevention and control of CHD. Methods A total of 18 254 subjects aged 18 years or older undergoing regular physical examinations at Beijing Friendship Hospital affiliated to Capital Medical University from January to December in 2012 were investigated by questionnaires, physical examination and laboratory tests. The effects of different MS components, Number and the association of different combinations of components with CHD prevalence. Results The prevalence of MS in 18 254 ≥18 years old was 29.83% and the prevalence of CHD was 1.05%. The correlation analysis between MS and CHD showed that overweight or obesity, hypertension, hypertriglyceridemia Disease, low-density lipoproteinemia, hyperglycemia or diabetes mellitus were all risk factors for CHD (all P <0.01). Correlation analysis between the number of MS and CHD showed that when the number of components The risk of CHD was higher when the number of MS was 4 (OR = 3.16, 95% CI = 1.94-5.14) and 5 (OR = 4.12, 95% CI = 1.59-10.72) The results of correlation analysis with CHD showed that the risk of CHD in BMI + HDL-C group was relatively low (OR = 0.06, 95% CI = 0.02) when the number of components was 2 ~ 0.24). The risk of CHD was higher in BP + FPG group (OR = 4.60,95% CI = 1.44-14.69). When the number of components was 3, BP + FPG + HDL- The risk of CHD in group C was relatively high (OR = 5.08, 95% CI = 1.15-22.40). When the number of components was 4, BM I + BP + triglycerides (TG) % CI = 1.03-18.61) and BM I + BP + FPG + HDL-C group (OR = 4.33,95% CI = 1.20-15.66). Conclusions M S component is a risk factor for CHD. The risk of CHD increases with the increase of M S components. The correlation between CHD and different combinations is different when the number of components is the same.