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本文报告44例恶性胶质细胞瘤病人的再手术效果,其中多形胶质母细胞瘤13例(29.6%),星形细胞瘤Ⅲ~Ⅳ级31例(70.4%);第一二次手术间隔平均为78.5周;再手术前KR为20~90(平均56):8例病人接受一次以上再手术.手术死亡率为每次手术1.9%;再手术后平均存活期为52.7周:35例(79.5%)术后一个月时KR较术前改善,术后KR≥60的时间平均为25.2周;术前KR≥60、手术间隔时间>6个月、术中全切肿瘤的病人术后生存期较相应组明显延长(P<0.001).提出再手术治疗复发性恶性胶质瘤是可行的,但术前KR≥60,手术间隔＞6个月及术中全切肿瘤者将获得较好效果.
This article reports the reoperation effect of 44 patients with glioblastoma, including 13 cases of glioblastoma (29.6%), 31 cases (70.4%) of grade Ⅲ ~ Ⅳ astrocytoma; the first second surgery The average interval was 78.5 weeks. Before reoperation, the KR was 20-90 (average 56): 8 patients underwent more than one reoperation, and the operative mortality was 1.9% for each operation. The mean survival time after reoperation was 52.7 weeks: 35 (79.5%) at one month after surgery, the KR was improved compared with that before operation. The average time of postoperative KR≥60 was 25.2 weeks. The preoperative KR≥60 and the operation time> 6 months. Survival was significantly longer than the corresponding group (P <0.001) .Reoperation for the treatment of recurrent glioblastoma is feasible, but the preoperative KR≥60, surgery interval> 6 months and total resection of the tumor will get more Good effect.