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目的探讨血清25羟维生素D水平与妊娠期高血压疾病之间的相关性。方法采用电化学发光免疫分析法检测163名妊娠期高血压疾病患者(其中A组妊娠期高血压56人、B组轻度子痫前期62人和C组重度子痫前期45人)及86名正常妊娠孕妇(对照组)在不同孕周时的血清25羟维生素D水平,分析25羟维生素D与妊娠期高血压疾病的相关性。结果在妊娠12~18周、30~36周时,对照组25羟维生素D水平为(19.2±3.14)和(23.5±2.15)ng/m L;A组为(18.6±2.35)和(20.3±2.13)ng/m L;B组为(12.4±0.34)和(17.5±1.46)ng/m L;C组为(9.6±1.45)和(11.1±2.26)ng/m L。A组与对照组的25羟维生素D水平差异无统计学意义(P>0.05),B、C两组25羟维生素D水平均明显低于对照组(P<0.01)。结论 25羟维生素D的下降与子痫前期的发病相关,且早于子痫前期临床症状的出现,有预测子痫前期发生的作用。
Objective To investigate the correlation between serum 25-hydroxyvitamin D levels and gestational hypertension. Methods Electrochemiluminescence immunoassay was used to detect 163 patients with gestational hypertension (group A with 56 gestational hypertension, group B with mild preeclampsia 62 and group C with severe preeclampsia 45) and 86 The levels of serum 25-hydroxyvitamin D in normal pregnant women (control group) at different gestational weeks were analyzed. The correlation between 25-hydroxyvitamin D and gestational hypertension was analyzed. Results The levels of 25-hydroxyvitamin D in the control group were (19.2 ± 3.14) and (23.5 ± 2.15) ng / m L at the age of 18-18 and 30-36 weeks of gestation; those in the group A were (18.6 ± 2.35) and 2.13) ng / m L; (12.4 ± 0.34) and (17.5 ± 1.46) ng / m L in group B and (9.6 ± 1.45) and (11.1 ± 2.26) ng / m L in group C, respectively. There were no significant differences in 25-hydroxyvitamin D between group A and control group (P> 0.05). The levels of 25-hydroxyvitamin D in group B and C were significantly lower than those in control group (P <0.01). Conclusions The decrease of vitamin D is associated with the onset of preeclampsia and earlier than the onset of clinical symptoms of preeclampsia. It may predict the occurrence of preeclampsia.