研究成骨细胞的分化过程和调节,对理解骨质疏松具有重要意义。成骨细胞来自骨髓多功能干细胞,后者也产生成纤维细胞、肌母细胞、软骨细胞和脂肪细胞。每种细胞的分化由其前体细胞决定,不能逆转。近年来许多研究表明,体外培养的成骨细胞前体及成骨细胞可进一步转化为脂肪细胞,这种转化对研究骨质疏松的发病机理具有重要意义。 Studying the process of osteoblast differentiation and regulation is of great significance for the understanding of osteoporosis. Osteoblasts are derived from bone marrow pluripotent stem cells, which also produce fibroblasts, myoblasts, chondrocytes and adipocytes. The differentiation of each cell is determined by its precursor cells and can not be reversed. In recent years, many studies have shown that in vitro cultured osteoblast precursors and osteoblasts can be further transformed into adipocytes, and this transformation is of great significance for studying the pathogenesis of osteoporosis.