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目的:为探讨突变型P53蛋白、PCNA(增殖细胞核抗原)的表达与肺癌病理组织学的关系.方法:应用免疫组化ABC法检测112例原发性肺癌的P53蛋白、PCNA的表达.结果:①突变型P53表达的阳性率为45%;②突变型P53与PC-NA的表达关系密切,PCNA强阳性的P53强阳性率为86%,显著高于其他组(P<0.01);③P53强阳性率、PCNA强阳性率均以腺癌组为最低(P<0.05);④P53、PCNA的表达与肺癌分期间的关系不密切(P>0.05).结论:提示突变型P53蛋白、PCNA的表达可作为肺癌患者预后判断的客观指标.
Objective: To investigate the relationship between the expression of mutant P53 protein and PCNA (proliferating cell nuclear antigen) and pathological histology of lung cancer. Methods: To detect the expression of P53 protein and PCNA in 112 cases of primary lung cancer by immunohistochemical ABC method. 1 The positive rate of mutant P53 expression was 45%; 2 The expression of mutant P53 was closely related to PC-NA, and the strong positive rate of PCNA was 86%, which was significantly higher than that of other groups (P<0.01); 3P53 was strong The positive rate and PCNA strong positive rate were the lowest in the adenocarcinoma group (P<0.05). The expression of 4P53 and PCNA was not closely related to the lung cancer period (P>0.05). Conclusion: The expression of mutant P53 protein and PCNA was suggested. Can be used as an objective indicator of prognosis of lung cancer patients.